GLP-1 medications like Ozempic, Wegovy, and Mounjaro have reshaped the landscape of weight loss and type 2 diabetes management. At Apothecary & Co., we support evidence-based therapies–but we also believe health isn't just about what the scale says. What we're seeing in our community is clear: as food intake goes down, nutrient needs are being overlooked, and key systems in the body are being affected–sometimes in surprising ways.
This blog outlines the most important ways to support your body on a GLP-1 and highlights why nutrition, movement, and education are more critical now than ever.
Grounding Our Advice in the 8 Key Nutrition Priorities
We align our care recommendations with the American Society for Nutrition's 8 Key Nutrition Research Priorities, ensuring that we're not just addressing symptoms, but promoting whole-body health:
Advance and implement personalized nutrition - We help clients customize supplement and lifestyle plans based on their unique GLP-1 journey.
Improve nutritional patterns and behaviors - By focusing on nutrient density, meal timing, and mindful eating, we aim to build sustainable habits.
Support optimal growth and development - Especially critical for individuals in younger age groups or planning families, where nutrient status affects long-term outcomes.
Reduce nutrition-related health disparities - We provide education and access to foundational supplements regardless of socioeconomic background.
Advance food and nutrition security - Our guidance ensures people on GLP-1s meet nutrient needs even with reduced appetite.
Promote health and reduce chronic disease - We target inflammation, blood sugar balance, and heart health through strategic supplementation.
Develop and leverage tools, technology, and data - We use lab work, symptom tracking, and up-to-date research to guide care.
Enhance translation and dissemination of nutrition science - Through classes, blogs like this, and 1:1 consultations, we make nutrition science accessible and actionable.
1. GLP-1s Can Lead to Nutrient Deficiencies
When appetite goes down, nutrient intake often follows. That's one of the unintended consequences of these medications.
A 2023 study in Obesity found that patients on GLP-1s had reduced intake of protein, magnesium, B vitamins (especially B12), calcium, and vitamin D–even when following standard diets. These shortfalls can affect energy, sleep, gut health, bone strength, and mental clarity.
At Apothecary & Co., we're seeing more people with:
Fatigue
Constipation
Mood swings
Slowed metabolism
Muscle loss
Hormonal changes
Many of these symptoms trace back to missing the foundations.
2. Vision & Eye Health: An Overlooked Risk
Some research is exploring a connection between GLP-1 medications and changes in eye health, particularly in people with existing diabetes.
A 2023 study published in JAMA Ophthalmology observed that semaglutide use was associated with diabetic retinopathy progression in certain patients, potentially due to rapid blood sugar improvements. The risk appears highest in individuals with pre-existing eye conditions or poorly controlled glucose prior to starting.
While more research is needed, these findings highlight the importance of:
Regular eye exams
Balanced blood sugar improvements
Supporting B vitamin and antioxidant intake
Our Active B Complex and Omega-3 Essentials may offer support for nerve and eye health as part of a foundational supplement plan.
3. Contraception: What You Need to Know (Especially If You're on the Pill)
If you're of childbearing age and taking a GLP-1 medication, contraception is a critical conversation to have with your healthcare provider.
GLP-1s like Ozempic and Wegovy slow gastric emptying, which can interfere with how the body absorbs oral medications–including birth control pills.
A 2021 review in Diabetes Therapy emphasized that oral contraceptives may be less effective when taken alongside GLP-1 receptor agonists due to delayed gastric emptying. Because of this, non-oral methods of contraception like IUDs, injections, or implants are strongly recommended.
In addition:
GLP-1s are not recommended during pregnancy
Animal studies have shown potential harm to fetal development, including fetal loss and birth defects
Women are advised to discontinue GLP-1 therapy at least two months before attempting pregnancy
So, if you're using hormonal birth control and also taking a GLP-1 medication, consider speaking with your healthcare provider about switching to a non-oral method for reliable protection.
4. Constipation on GLP-1s Is Real – and Fixable
Studies show up to 30% of GLP-1 users experience constipation, often due to slowed gastric motility. This isn't just uncomfortable–it can interfere with detoxification, microbiome balance, and appetite signals.
We recommend Magnesium Citrate, which works gently by pulling water into the bowels. Our capsules are free from artificial fillers and typically effective with 300-400 mg at bedtime, depending on individual needs.
5. Protecting Muscle Mass During Weight Loss
A major concern with GLP-1-induced weight loss is loss of lean muscle, which slows metabolism and increases the risk of regaining fat.
A 2022 study in Diabetes, Obesity and Metabolism showed that up to 39% of weight lost on semaglutide was lean body mass, not just fat.
What helps:
Eating 80-120g of protein per day (depending on goals)
Resistance training 2-4x/week
Supplementing with amino acids or collagen when protein intake is low
We support our clients with smart movement routines, easy protein add-ins, and guidance on sustainable weight loss–without sacrificing health.
6. Apothecary & Co Foundational Support
These are our top product picks for people on GLP-1s:
Magnesium Citrate - For gentle, regular bowel movements
Active B Complex - Methylated Bs for energy, nerve, and eye support
Omega-3 Essentials - Inflammation and brain support, also key for eye and heart health
Probiotic Essentials - Gut support to balance digestion and nutrient absorption
We help you tailor a supplement plan that fits your goals, symptoms, and lab work.
7. You're Not Alone – We're Here to Help
GLP-1s are a powerful tool. But they're not the whole solution. You need nourishment, movement, and ongoing care.
Whether you're just starting or are months into your journey, we invite you to stop in for support, guidance, and real conversation. We offer in-person consultations, professional-grade supplements, and a judgment-free space to learn how to care for your body at every stage of healing.
References
Sargeant, J. A., et al. (2023). Nutritional Intake in Individuals Taking GLP-1 Receptor Agonists. Obesity (Silver Spring). https://doi.org/10.1002/oby.23712
JAMA Ophthalmology. (2023). Risk of Diabetic Retinopathy Progression With GLP-1 Therapy. https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2807853
Ghosal, S., et al. (2021). GLP-1 RAs in Women of Reproductive Age: A Clinical Review. Diabetes Therapy. https://doi.org/10.1007/s13300-021-01009-6
Acosta, A., et al. (2021). Gastrointestinal Side Effects of GLP-1 Receptor Agonists. Diabetes, Obesity and Metabolism, 23(3), 523-533. https://doi.org/10.1111/dom.14234
Wilding, J. P. H., et al. (2022). Changes in Body Composition With Semaglutide Treatment. Diabetes, Obesity and Metabolism, 24(6), 1081-1090. https://doi.org/10.1111/dom.14653
